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We ALWAYS play Outbreak. I like the more intense, "ye must explore every turn" setup. That, combined with a high-damage mansion, can be pretty rough though.
So yeah, I'll probably swap Nemmy 1/Wasp x2 for Nemmy 2/Guardian x2 as far as damage-on-reveal effects go, but I'll probably need to swap out some other monsters too to keep the HP curve from getting too high.
Got to test my mansion; my buddy probably would have died several times (Primer Clare vs. Mercs Wesker; I was Wesker) if he didn't have... I believe Giant Killer 1, the one that nulls all damage from higher end monsters. I wound up getting the Rocket Launcher twice (mainly because I was suicide exploring with Wesker's shield :P), which wound up giving me the game. Overall, he felt like it was pretty well balanced.
Try the game with a group of four for a real test of your mansion's power. The game is substantially easier with only two players since you each have many more opportunities to kill low-end monsters.
As for my mansion, I've decided to leave it as-is. After repeated plays, 20 damage Nemmy + 2 Wasps + 2 Yawns feels pretty good. I don't think I'll be making any further revisions until the next set comes out.
Let me know how your mansion works out for you after a few more games.