Almost done with my first run on very hard, but on hard I had never beaten it without dying, usually Alexia's second form literally tentacle raped me. Anyway, on very hard, I'm playing through, blowing everything up and shooting dead things; make it to Alexia and blast her face with the handgun. She transforms, I switch to automatic and shotgun, get her below half as soon as I've made it past the tentacles. Hit the zone and kill second form with one hit on me. Make it through the third form after the FAS and boom, GoO 7 Expert for beating without dying.
I'm still scratching my head on this one.